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Animal Care Services
Office: H1848
acs@mun.ca
(709) 777-6620 or 6621
Fax: (709) 777-8468

1. What are the scientific justification s for using death or "moribund" as the proposed endpoint?
2. What is the expected time course for the animals, from initial treatment to first signs of pain/distress to the death of the animal, based on previous information with the specific model under study?
3. When are the effects to the animal expected to be the most severe?
4. Has a "checklist of observations," on which the endpoint will be based, been established?
5. If the course of the disease and expected signs of the negative effects is unknown, could an initial (pilot) study, under close observation by the laboratory animal veterinary staff, answer these questions?
6. Who will monitor the animals (identify all responsible)?
7. What will be the frequency of animal observations: a) during the course of the study, and b) during critical times for the animals?
8. What provisions have been made to deal with any animals that show unexpectedly severe signs and symptoms?

Guidelines on:

choosing an appropriate endpoint
in experiments using animals for
research, teaching and testing

See CCAC guidelines on website: http://www.ccac.ca/